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KMID : 1022820210120020060
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Journal of Multiple Sclerosis and Neuroimmunology
2021 Volume.12 No. 2 p.60 ~ p.63
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A Case of Progressive Multifocal Leukoencephalopathy in Systemic Lupus Erythematosus While Titrating Mycophenolate Mofetil with Low-Dose Corticosteroid
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Kang Il-Mo
Lee Sang-Gon
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Abstract
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Progressive multifocal leukoencephalopathy (PML) is a fatal demyelinating disease caused by the reactivation of human polyomavirus JC in immunosuppressed patients. We report a systemic lupus erythematosus (SLE) patient diagnosed with definite PML after titration of mycophenolate mofetil based on characteristic MRI findings. After all, the patient eventually went through a fatal clinical course. PML should be considered in the differential diagnosis if SLE patient presents with new-onset focal neurological deficits, even during low-dose immunosuppressive therapy.
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KEYWORD
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Leukoencephalopathy, Progressive multifocal, Lupus erythematosus, Systemic, Mycophenolic acid
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